Clinical & Experimental Metastasis

, Volume 6, Issue 2, pp 115–120

Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan

Authors

  • J. Beuth
    • Institute of HygieneUniversity of Cologne
  • H. L. Ko
    • Institute of HygieneUniversity of Cologne
  • V. Schirrmacher
    • Deutsches Krebsforschungszentrum
  • G. Uhlenbruck
    • Department of ImmunobiologyMedical University Clinic I
  • G. Pulverer
    • Institute of HygieneUniversity of Cologne
Article

DOI: 10.1007/BF01784842

Cite this article as:
Beuth, J., Ko, H.L., Schirrmacher, V. et al. Clin Exp Metast (1988) 6: 115. doi:10.1007/BF01784842

Abstract

Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

Copyright information

© Kluwer Academic Publishers 1988