Klinische Wochenschrift

, Volume 62, Issue 2, pp 93–96

Bone mineral content after renal transplantation

Placebo-controlled prospective study with 1,25-dihydroxy vitamin D3
  • E. Neubauer
  • N. Neubauer
  • E. Ritz
  • K. Dreikorn
  • K. -H. Krause
Kurze Wissenschaftliche Mitteilungen

DOI: 10.1007/BF01769669

Cite this article as:
Neubauer, E., Neubauer, N., Ritz, E. et al. Klin Wochenschr (1984) 62: 93. doi:10.1007/BF01769669

Summary

Forearm bone mineral content (BMC), as evaluated by photonabsorption densitometry, was measured in 28 cadaver kidney donor recipients who entered the study 8 weeks postoperatively and were followed up for 18 months. BMC decreased signifiantly (p<0.05) but marginally in placebo-treated patients (n=14) (initial BMC 1.09±0.25 g/cm; final BMC 1.05±0.24). Fourteen patients were prophylactically given 1,25(OH)2vitamin D3 in a dose which avoided hypercalcemia and hypercalciuria (∼0.25 µg/day); under 1,25(OH)2 vitamin D3 prophylaxis a significant decrease of forearm BMC was observed no longer (initial BMC 0.94±0.21 g/cm; final BMC 0.95±0.21), but the difference between placebo and 1,25(OH)2 vitamin D3 narrowly missed statistical significance (p=0.066).

It is concluded that the decrease of forearm BMC is negligible in transplant recipients with low steroid regimens. The data suggest a trend for prophylaxis with 1,25(OH)2 vitamin D3 to slightly ameliorate forearm (cortical) BMC loss.

Key words

Renal transplantationSteroid osteoporosis1,25-Dihydroxy vitamin D3Immunosuppressive therapy

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • E. Neubauer
    • 1
  • N. Neubauer
    • 1
  • E. Ritz
    • 1
  • K. Dreikorn
    • 1
  • K. -H. Krause
    • 1
  1. 1.Depts. of Internal Medicine, Urology, and NeurologyUniversity of HeidelbergGermany