, Volume 7, Issue 1 Supplement, pp 73-80

HLA-Linked susceptibility and resistance to Takayasu Arteritis

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Summary

To investigate genetic factors involved in the pathogenesis of Takayasu arteritis, patients in the Japanese population were examined forHLA-A, -B, and-C alleles by serological typing and forHLA-DR, DQ, andDP alleles by DNA typing using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probe (SSOP) analysis. The frequencies ofHLA-Bw52, DRB1 *1502,DRB5 *0102,DQA1 *0103,DQB1 *0601, andDPB1 *0901 alleles were significantly increased and the frequencies ofHLA-Bw54, DRB1 *0405,DRB4 *0101,DQA1 *0301, andDQB1 *0401 alleles were significantly decreased. Strong linkage disequilibria among the increased alleles and among the decreased alleles were evident in the Japanese population. Therefore, the haplotype ofHLA-Bw52-DRB1 *1502-DRB5*0102-DQA1*0103-DQB1*0601-DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another haplotype ofHLA-Bw54-DRB1 *0405-DRB4*0101-DQA1*0301-DQB1*0401 may confer resistance to the disease. These observations clearly indicate thatHLA-linked gene(s) are involved in the development of Takayasu arteritis.