Heart and Vessels

, Volume 7, Supplement 1, pp 73–80

HLA-Linked susceptibility and resistance to Takayasu Arteritis

  • Rui-Ping Dong
  • Akinori Kimura
  • Fujio Numano
  • Yasuharu Nishimura
  • Takehiko Sasazuki
Article

DOI: 10.1007/BF01744548

Cite this article as:
Dong, RP., Kimura, A., Numano, F. et al. Heart Vessels (1992) 7(Suppl 1): 73. doi:10.1007/BF01744548

Summary

To investigate genetic factors involved in the pathogenesis of Takayasu arteritis, patients in the Japanese population were examined forHLA-A, -B, and-C alleles by serological typing and forHLA-DR, DQ, andDP alleles by DNA typing using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probe (SSOP) analysis. The frequencies ofHLA-Bw52, DRB1*1502,DRB5*0102,DQA1*0103,DQB1*0601, andDPB1*0901 alleles were significantly increased and the frequencies ofHLA-Bw54, DRB1*0405,DRB4*0101,DQA1*0301, andDQB1*0401 alleles were significantly decreased. Strong linkage disequilibria among the increased alleles and among the decreased alleles were evident in the Japanese population. Therefore, the haplotype ofHLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601-DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another haplotype ofHLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1*0401 may confer resistance to the disease. These observations clearly indicate thatHLA-linked gene(s) are involved in the development of Takayasu arteritis.

Key words

Takayasu arteritis HLA Typing Disease susceptibility gene Sequence-specific oligonucleotide probe (SSOP) Polymerase chain reaction (PCR) 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Rui-Ping Dong
    • 1
  • Akinori Kimura
    • 1
  • Fujio Numano
    • 2
  • Yasuharu Nishimura
    • 1
  • Takehiko Sasazuki
    • 1
  1. 1.The Department of Genetics, Medical Institute of BioregulationKyushu UniversityFukuokaJapan
  2. 2.The Third Department of Internal MedicineTokyo Medical and Dental UniversityTokyoJapan

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