European Journal of Clinical Pharmacology

, Volume 43, Issue 2, pp 121–124

Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times

Use in studying the actions of cisapride in diabetic patients
  • J. F. Bergmann
  • O. Chassany
  • P. J. Guillausseau
  • M. Bayle
  • S. Chagnon
  • C. Caulin
  • J. R. Sallenave
Originals

DOI: 10.1007/BF01740656

Cite this article as:
Bergmann, J.F., Chassany, O., Guillausseau, P.J. et al. Eur J Clin Pharmacol (1992) 43: 121. doi:10.1007/BF01740656

Summary

The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design.

It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.

Key words

CisaprideDiabetic neuropathygastric emptyingorocaecal transit timegastroparesiscontrolled trial

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. F. Bergmann
    • 1
  • O. Chassany
    • 1
  • P. J. Guillausseau
    • 2
  • M. Bayle
    • 3
  • S. Chagnon
    • 4
  • C. Caulin
    • 1
  • J. R. Sallenave
    • 5
  1. 1.Unité de Recherches ThérapeutiquesHôpital LariboisièreParisFrance
  2. 2.Department of EndocrinologyLariboisière HospitalParisFrance
  3. 3.Department of PharmacyLariboisière HospitalParisFrance
  4. 4.Department of RadiologyLariboisière HospitalParisFrance
  5. 5.Janssen LaboratoriesBoulogne BillancourtFrance