Molecular and Cellular Biochemistry

, Volume 14, Issue 1, pp 11–14

Genetic determination of the mitochondrial adenine nucleotide translocation system and ITS role in the eukaryotic cell

  • Ladislav Kováč
  • Jordan Kolarov
  • Julius Šubík
Article

DOI: 10.1007/BF01734158

Cite this article as:
Kováč, L., Kolarov, J. & Šubík, J. Mol Cell Biochem (1977) 14: 11. doi:10.1007/BF01734158

Summary

On integrating experimental data published previously, the following picture of the mitochondrial adenine nucleotide(AdN) translocation system is being presented:

  1. 1.

    The AdN translocation system serves not only to transport ATP synthesized within mitochondria into the cytosol but also to transport cytosolic ATP into the mitochondria when oxidative phosphorylation is not functioning.

     
  2. 2.

    The AdN translocator is coded for by nuclear genes and the mitochondrial protein synthesis is not involved in its formation.

     
  3. 3.

    The AdN translocation system must be preserved and functioning even in cells which could dispense with oxidative phosphorylation. It assures appropriate concentrations of intramitochondrial ATP.

     
  4. 4.

    The intramitochondrial ATP is required for normal replication of mitochondrial DNA. This supports the view that the mitochondrion is a self-replicating semi-autonomous organelle.

     
  5. 5.

    The appropriate concentration of ATP must be present in mitochondria to make possible cell growth or multiplication. This points to a direct or indirect role of mitochondria in the control of cell proliferation.

     

Copyright information

© Dr. W. Junk b.v. Publishers 1977

Authors and Affiliations

  • Ladislav Kováč
    • 1
  • Jordan Kolarov
    • 2
  • Julius Šubík
    • 3
  1. 1.Psychiatric HospitalPezinokCzechoslovakia
  2. 2.Institute of experimental oncologySlovak Academy of SciencesBratislavaCzechoslovakia
  3. 3.Food Research InstituteBratislavaCzechoslovakia