Journal of Molecular Evolution

, Volume 11, Issue 2, pp 171–187

Biotin. Its place in evolution

  • C. M. Visser
  • R. M. Kellogg

DOI: 10.1007/BF01733892

Cite this article as:
Visser, C.M. & Kellogg, R.M. J Mol Evol (1978) 11: 171. doi:10.1007/BF01733892


In the previous article we try to give an explanation for the success of models for enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.

Key words

Bioorganic chemistryBiotinOrigin of LifeCofactor ModelsProsthetic groupRNAChemical Evolution

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • C. M. Visser
    • 1
  • R. M. Kellogg
    • 1
  1. 1.Department of Organic ChemistryUniversity of GroningenNijenborghThe Netherlands