Biotin. Its place in evolution
- Cite this article as:
- Visser, C.M. & Kellogg, R.M. J Mol Evol (1978) 11: 171. doi:10.1007/BF01733892
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In the previous article we try to give an explanation for the success of models for enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.