, Volume 11, Issue 2, pp 171-187

Biotin. Its place in evolution

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


In the previous article we try to give an explanation for the success of models for enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.