Blut

, Volume 61, Issue 5, pp 314–316

Post-transfusion malaria in thalassaemia patients

  • N. J. Choudhury
  • M. L. Dubey
  • J. G. Jolly
  • Anju Kalra
  • R. C. Mahajan
  • N. K. Ganguly
Original article

DOI: 10.1007/BF01732885

Cite this article as:
Choudhury, N.J., Dubey, M.L., Jolly, J.G. et al. Blut (1990) 61: 314. doi:10.1007/BF01732885

Summary

A total of 125 β-thalassaemia patients receiving repeated blood transfusions were screened by Giemsa stain, Acridine-orange stain and antigen detection for evidence of malaria infection on each visit. A total of 8 (6.4%) of the patients developed post-transfusion malaria (PMT) as confirmed by tracing the infected blood donors. A high incidence of PTM in thalassaemia patients appears to be due to the use of fresh blood and the high frequency of blood transfusions required by these patients. Antigen detection using monoclonal antibody was found to be more sensitive for diagnosis of PTM and for screening suspected donors than the conventional blood smear examination methods and is therefore recommended for routine blood donor screening to rule out malaria infection.

Key words

Transfusion malariaThalassaemiaAntigen detection

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. J. Choudhury
    • 1
  • M. L. Dubey
    • 2
  • J. G. Jolly
    • 1
  • Anju Kalra
    • 2
  • R. C. Mahajan
    • 2
  • N. K. Ganguly
    • 3
  1. 1.Department of Blood Transfusion and ImmunohaematologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of ParasitologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of Experimental MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia