Are evolutionary rates really variable?
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Langley and Fitch (1974, 1976) have shown that the pattern of nucleotide substitutions in proteins is inconsistent with a Poisson process with constant rate. From this they conclude that the rate is temporally heterogeneous. It is pointed out in this note that a process which is temporally homogeneous but not a Poisson process is compatible with the data if the coefficient of variation of the time between substitutions is around 1.63. Furthermore, theoretical analysis of samples from neutral phylogenies shows that these samples should not appear to be samples from a Poisson process, but should deviate from a Poisson process in the same direction, though perhaps not to the same extent, as do the data.
- Cox, D.R., Miller, H.D, (1965). The Theory of Stochastic Processes. Methuen.
- Dobzhansky, T., Ayala, F.J., Stebbins, G.L., Valentine, J.W. (1977) Evolution San Francisco: Freeman and Co.
- Gillespie, J.H. (1977). Sampling theory for alleles in a random environment. Nature266, 443–445
- Kimura, M. (1968). Evolutionary rate at the molecular level. Nature217, 624–626
- Langley, C.H., Fitch, W.M. (1973). The constancy of evolution. A statistical analysis of theα andβ hemoglobins, cytochrome c and fibrinopeptide A. In: Genetic Structure of Populations (N.E. Morton, ed.) pp. 246–262, Honolulu: Univ. Press of Hawaii
- Langley, C.H., Fitch, W.M. (1974). An examination of the constancy of the rate of molecular evolution. J. Mol. Evol.3, 161–177
- Watterson, G.A. (1975). On the number of segregating sites in genetical models without recombination. Theor. Popul. Biol.7, 356–376
- Are evolutionary rates really variable?
Journal of Molecular Evolution
Volume 13, Issue 1 , pp 27-34
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