Journal of Molecular Evolution

, Volume 6, Issue 3, pp 209–214

Evolution of the haem-haem interaction in vertebrate haemoglobins - a hypothesis

  • S. Vuk-Pavlović

DOI: 10.1007/BF01732357

Cite this article as:
Vuk-Pavlović, S. J Mol Evol (1975) 6: 209. doi:10.1007/BF01732357


A hypothesis about the evolution of the haem-haem interaction in haemoglobins has been formulated on the basis of available functional and structural data. It emerges that this cooperative mechanism is not necessarily due solely to the higher levels of protomer aggregation, because it occurs only in haemoglobins having the distal histidine. It is thus proposed that this amino acid residue might have had a significant role for the development of low-oxygen-affinity haemoglobins in vertebrates.

Key words

Distal Histidine Haem-Haem Interaction Oxygen Affinity Protomer Aggregation 

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • S. Vuk-Pavlović
    • 1
  1. 1.Institute of ImmunologyZagrebYugoslavia

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