European Journal of Epidemiology

, Volume 10, Issue 2, pp 205–209

Association of alcohol consumption andHelicobacter pylori infection in young adulthood and early middle age among patients with gastric complaints

A case-control study on Finnish conscripts, officers and other military personnel
  • Mikko Paunio
  • Johanna Höök-Nikanne
  • Timo U. Kosunen
  • Unto Vainio
  • Mikko Salaspuro
  • Judit Mäkinen
  • Olli P. Heinonen
Article

DOI: 10.1007/BF01730371

Cite this article as:
Paunio, M., Höök-Nikanne, J., Kosunen, T.U. et al. Eur J Epidemiol (1994) 10: 205. doi:10.1007/BF01730371

Abstract

There is growing evidence thatHelicobacter pylori is responsible for a variety of gastric and duodenal changes which can eventually lead to stomach cancer. Little is known about risk factors forH. pylori infection. We re-analyzed the association of alcohol withH. pylori positivity in 451 conscripts, officers and other military personnel endoscoped due to gastric complaints in the Central Military Hospital of Finland in 1987 and 1988. Serology and culture were done in all patients. Alcohol consumption histories were obtained by use of a self-administered questionnaire. We observed a high odds ratio (OR) ofH. pylori infection among young adults who were heavy alcohol consumers compared to non-drinkers (OR 5.32, 95% confidence interval: 1.09–25.95). There was evidence of a dose response when heavy and moderate drinkers were compared to non-drinkers (Mantel-Haenszel χ2 for trend,p=0.02) in young adulthood. A subgroup of young respondents who reported drinking all classes of alcohol (including hard liquor) showed an even stronger association and more significant dose-response. Multivariate techniques revealed a qualitative interaction of alcohol withH. pylori positivity in different age groups and among old people an inverse association ofH. pylori and alcohol consumption was observed. These findings, if confirmed independently, might have implications for preventing a variety of gastric and duodenal lesions, since they allow identification of high risk groups.

Key words

Agealcohol consumptionCase-control studiesHelicobacter pylori

Abbreviations

95% CI

95% confidence interval

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Mikko Paunio
    • 1
  • Johanna Höök-Nikanne
    • 2
  • Timo U. Kosunen
    • 2
  • Unto Vainio
    • 3
  • Mikko Salaspuro
    • 4
  • Judit Mäkinen
    • 5
  • Olli P. Heinonen
    • 1
  1. 1.Department of Public HealthUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of Bacteriology and ImmunologyUniversity of HelsinkiFinland
  3. 3.Central Military Hospital of FinlandFinland
  4. 4.Research Unit of Alcoholic DiseasesUniversity of HelsinkiFinland
  5. 5.Peijas District Hospital VantaaFinland