Virus Genes

, Volume 11, Issue 2, pp 191–195

Retrovirus and filovirus “immunosuppressive motif” and the evolution of virus pathogenicity in HIV-1, HIV-2, and ebola viruses

  • Yechiel Becker
Part B: Molecular Processes Involved In The Evolution Of RNA And DNA Viruses

DOI: 10.1007/BF01728658

Cite this article as:
Becker, Y. Virus Genes (1995) 11: 191. doi:10.1007/BF01728658


The “immunosuppressive motif” was found to be present in the glycoproteins of retroviruses and filoviruses. This sequence is also conserved in the pathogenic lentiviruses, HIV-1 and SIV, and is absent from HIV-2 gp41 and from an apathogenic simian retrovirus. The present analysis deals with the possible involvement of the “immunosuppresessive motif” in the pathogenicity of retroviruses and filoviruses, and the reasons for the conservation of this motif. The ancestral gene from which the “immunosuppressive motif” originated is not known.

Key words

retroviruses lentiviruses HIV-1 HIV-2 SIV pathogenic MAC retrovirus filoviruses Ebola viruses immunodeficiency motif 

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Yechiel Becker
    • 1
  1. 1.Department of Molecular Virology, Institute of Microbiology, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

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