Klinische Wochenschrift

, Volume 66, Issue 17, pp 768–772

Atrial natriuretic peptide in human urine

  • K. Ando
  • N. Umetani
  • T. Kurosawa
  • S. Takeda
  • Y. Katoh
  • F. Marumo
Originalien

DOI: 10.1007/BF01726575

Cite this article as:
Ando, K., Umetani, N., Kurosawa, T. et al. Klin Wochenschr (1988) 66: 768. doi:10.1007/BF01726575

Summary

A highly sensitive radioimmunoassay to measure atrial natriuretic peptide (ANP) concentration in urine has been established, and its clinical usefulness is presented. ANP in urine was stable at 4° C for several days and was easily measured by our radioimmunoassay. The average ANP excretion in 65 healthy persons was 25.0±1.4 ng/day (mean ± SEM) and the fractional excretion of ANP was 0.7±0.05%. In 14 patients with congestive heart failure, the average ANP excretion was 119.2±29.4 ng/day, which decreased to 53.3±11.0 after successful treatment.

Key words

Atrial natriuretic peptide Urine Human Renal disease Congestive heart failure 

Abbreviations

ANP

atrial natriuretic peptide

hANP

human atrial natriuretic peptide

RIA

radioimmunoasay

NSB

non specific bound

FEANP

the fractional excretion of atrial natriuretic peptide

FENa

the fractional excretion of sodium

SIADH

the syngrome of inappropriate secretion of antidiuretic hormone

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Ando
    • 1
  • N. Umetani
    • 2
  • T. Kurosawa
    • 2
  • S. Takeda
    • 2
  • Y. Katoh
    • 2
  • F. Marumo
    • 3
  1. 1.Kitasato Biochemical Laboratories, Bristol-Myers, SagamiharaKanagawaJapan
  2. 2.Department of MedicineKitasato University School of MedicineSagamiharaJapan
  3. 3.Second Department of Internal MedicineTokyo Medical and Dental University, YushimaTokyoJapan