Pulmonary disposition of vancomycin in critically ill patients

  • H. Georges
  • O. Leroy
  • S. Alfandari
  • B. Guery
  • M. Roussel-Delvallez
  • C. Dhennain
  • G. Beaucaire
Notes

DOI: 10.1007/BF01726369

Cite this article as:
Georges, H., Leroy, O., Alfandari, S. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1997) 16: 385. doi:10.1007/BF01726369

Abstract

Vancomycin penetration in epithelium lining fluid was studied in ten mechanically ventilated patients with methicillin-resistantStaphylococcus aureus pneumonia 24 hours after the onset of treatment. Vancomycin was given intravenously at a daily dose of 30 mg/kg. Vancomycin levels were detectable in four patients (range, 1–2.77 μg/ml). Concordance between high plasma concentrations (> 20 μg/ml) and detectable vancomycin levels in epithelium lining fluid was noted. These results suggest that the pulmonary disposition of vancomycin remains low for most patients 24 h after the onset of treatment compared with the minimum inhibitory concentrations for most gram-positive organisms. One therapeutic goal of vancomycin treatment could be to obtain through plasma levels of 20 μg/ml. Further studies are required to determine the clinical relevance of these observations.

Copyright information

© MMV Medizin Verlag GmbH Munchen 1997

Authors and Affiliations

  • H. Georges
    • 1
  • O. Leroy
    • 1
  • S. Alfandari
    • 1
  • B. Guery
    • 1
  • M. Roussel-Delvallez
    • 2
  • C. Dhennain
    • 3
  • G. Beaucaire
    • 1
  1. 1.Service Universitaire de Réanimation Médicale et Maladies InfectieusesHôpital ChatilliezTourcoingFrance
  2. 2.Laboratoire de Bacteriologie, Hôpital A. CalmetteLille University Medical SchoolFrance
  3. 3.Laboratoire de BacteriologieHôpital ChatilliezTourcoingFrance