Summary
With the advent of combinatorial chemistry a new paradigm is evolving in the field of drug discovery. The approach is based on an integration of chemistry, high-throughput screening and automation engineering. The chemistry arm is usually based on solid-phase synthesis technology as the preferred approach to library construction. One of the most powerful of the solid-phase methods is encoded split synthesis, in which the reaction history experience by each polymeric bead is unambiguously recorded. This split-and-pool approach, employing chemically robust tags, was used to construct a 85 000-membered dihydrobenzopyran library.
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Baldwin, J.J. Design, synthesis and use of binary encoded synthetic chemical libraries. Mol Divers 2, 81–88 (1996). https://doi.org/10.1007/BF01718704
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DOI: https://doi.org/10.1007/BF01718704