Sequence analysis of pre-S/S gene of hepatitis B virus strains of genotypes A, D, and F isolated in Brazil
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- Moraes, M.T.B., Gomes, S.A. & Niel, C. Archives of Virology (1996) 141: 1767. doi:10.1007/BF01718299
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The nucleotide sequences of pre-S/S gene of nine hepatitis B virus strains (3adw2, 3ayw2, and 3ayw3) and of pre-S region of twoadw4 isolates from Rio de Janeiro, Brazil, were determined. Phylogenetic analysis allowed to classify these strains into three genotypes, A, D and F, reflecting the diverse origin of the population. However, strains belonging to a same genotype were separated by a short evolutionary distance. The presence of aminoacid mutations into pre-S region not found in hepatitis B viruses isolated in other parts of the world is described.