, Volume 60, Issue 14, pp 756-758

Suggested importance of monokines in pathophysiology of endotoxin shock and malaria

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There are many similarities in the pathophysiology of gram-negative infections and in acute falciparum malaria. Particularly, noteworthy is the detection of circulating inflammatory mediators in animals receiving endotoxin and in animals infected with malarial parasites. These observations have lead to the notion that macrophage derived mediators may be responsible, at least in part, for the pathology observed in malaria.