Intensive Care Medicine

, Volume 20, Issue 4, pp 291–297

Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution

1. Physiologic concepts
  • B. E. Marshall
  • C. Marshall
  • F. Frasch
  • C. W. Hanson
Basic Science Series

DOI: 10.1007/BF01708968

Cite this article as:
Marshall, B.E., Marshall, C., Frasch, F. et al. Intensive Care Med (1994) 20: 291. doi:10.1007/BF01708968

Abstract

The regulation of the distribution of ventilation/perfusion ratios by hypoxic pulmonary vasoconstriction contributes to both the efficiency of gas exchange and to pulmonary hemodynamics. In this review, the first of a two part series, are summarized the physiologic principles on which the analysis of ventilation/perfusion ratios and of pressure — flow relationships are based. A new combined analysis is introduced that permits the important contributions of hypoxic pulmonary vasoconstriction to overall gas exchange to be demonstrated in the circumstances of clinical complexity.

Key words

LungVentilation/perfusionPressure-flowComputer model

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • B. E. Marshall
    • 1
  • C. Marshall
    • 1
  • F. Frasch
    • 1
  • C. W. Hanson
    • 1
  1. 1.Center for Anesthesia ResearchUniversity of Pennsylvania School of MedicinePhiladelphiaUSA