Intensive Care Medicine

, Volume 21, Issue 7, pp 584–589

Effects of intravenous ketamine on gastrointestinal motility in the dog

  • J. Fass
  • R. Bares
  • V. Hermsdorf
  • V. Schumpelick
Original

DOI: 10.1007/BF01700164

Cite this article as:
Fass, J., Bares, R., Hermsdorf, V. et al. Intensive Care Med (1995) 21: 584. doi:10.1007/BF01700164

Abstract

Objective

The purpose of this trial was to clarify the effets of intravenous ketamine at anaesthetic and sub-anaesthetic dosages on gastrointestinal motility.

Design

20 beagles (group 1: 3 mg/ketamine/kg/h,n=10; group 2: 30 mg ketamine/kg/h,n=10), were investigated. Gastric emptying (nuclide gastric emptying studies, liquid and semi-solid test meal), intestinal transit time (Hydrogen breath test with lactulose) and intestinal motor function (perfusion manometry with 8 measuring ports) were determned. As a control condition, the tests were performed on all dogs in the two groups during infusion of physiological saline solution.

Results

No significant differences in the motility patterns were present between 3 mg ketamine/kg/h and the control condition. For group 2, a moderately significant (p<0.05) increase in the interdigestive motility index was observed for 30 mg k ketamine/kg/h. However, this did not change the transit criteria. There was no significant difference between ketamine and control condition tests with regard to cycle and phase lengths or the propagation rate of the activity front.

Conclusions

We conclude that ketamine provokes no basic changes in gastrointestinal motility, at either sub-anaesthetic doses. It can there-fore be used to advantage in the continuous postoperative analgesia of intensive care patients, where repeated interventions are necessary and no cardiopulmonary contraindications are present.

Key words

KetamineGastrointestinal motilityPain, post-operativeCritical care

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. Fass
    • 1
  • R. Bares
    • 2
  • V. Hermsdorf
    • 1
  • V. Schumpelick
    • 1
  1. 1.Department of SurgeryRWTH AachenAachenGermany
  2. 2.Department of Nuclear MedicineRWTH AachenAachenGermany