Annals of Hematology

, Volume 69, Issue 2, pp 81–84

Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count

  • P. J. J. van Genderen
  • J. J. Michiels
  • S. C. P. A. M. van der Poel-van de Luytgaarde
  • H. H. D. M. van Vliet
Case Report

DOI: 10.1007/BF01698487

Cite this article as:
van Genderen, P.J.J., Michiels, J.J., van der Poel-van de Luytgaarde, S.C.P.A.M. et al. Ann Hematol (1994) 69: 81. doi:10.1007/BF01698487

Summary

We present a 4-year follow-up of a 42-year-old patient with primary thrombocythemia whose clinical course was complicated by two major mucocutaneous bleeding episodes. On both occasions an acquired functional von Willebrand factor deficiency was demonstrated. In contrast to what is reported in the literature, an inverse relationship between platelet number and plasma high-molecular-weight multimers of von Willebrand factor was established.

Key words

Primary thrombocythemia Myeloproliferative disorder von Willebrand factor Acquired von Willebrand disease Platelets Bleeding 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. J. J. van Genderen
    • 1
  • J. J. Michiels
    • 1
  • S. C. P. A. M. van der Poel-van de Luytgaarde
    • 1
  • H. H. D. M. van Vliet
    • 1
  1. 1.Department of Hematology, University Hospital DijkzigtErasmus UniversityGD RotterdamThe Netherlands