Cancer Causes & Control

, Volume 5, Issue 5, pp 409–413

Prevalence of second generation antibody to hepatitis C virus among voluntary blood donors in Osaka, Japan

  • Hideo Tanaka
  • Tomohiko Hiyama
  • Hideaki Tsukuma
  • Yasuto Okubo
  • Hajime Yamano
  • Akira Kitada
  • Isaburo Fujimoto
Research Papers

DOI: 10.1007/BF01694754

Cite this article as:
Tanaka, H., Hiyama, T., Tsukuma, H. et al. Cancer Causes Control (1994) 5: 409. doi:10.1007/BF01694754
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Abstract

To clarify the demographic characteristics of the prevalence of hepatitis C virus (HCV) infection in Osaka, Japan, where hepatocellular carcinoma is common, we investigated the screening data of antibody to HCV (anti-HCV, DAINABOTHCVPHA, second generation assay) in 197,600 voluntary blood donors residing in Osaka. The study found that age-standardized prevalence of anti-HCV was significantly higher than that of HBsAg (2.25cf 0.86 percent among males,P<0.001; 2.17cf 0.55 percent among females,P<0.001. It was much higher in the blood donors aged 55–64 years than in those aged 16–54 years (8.49cf 1.32 percent among males,P<10−5; 7.26cf 1.42 percent among females,P<10−5). The prevalence of anti-HCV among males was significantly higher than that of females in the younger (25–34 years) generations (1.02 to 1.49 percentcf 0.71 to 1.13 percent,P<0.05). A similar tendency was observed in the prevalence of high-titer (≧212) anti-HCV. The number of coinfection (both HBsAg and anti-HCV seropositive) was very small, and it was not statistically different from the expected number.

Key words

Blood donorshepatitis B virushepatitis C virushepatocellular carcinomaJapan

Copyright information

© Rapid Communications of Oxford Ltd 1994

Authors and Affiliations

  • Hideo Tanaka
    • 1
  • Tomohiko Hiyama
    • 1
  • Hideaki Tsukuma
    • 1
  • Yasuto Okubo
    • 2
  • Hajime Yamano
    • 2
  • Akira Kitada
    • 2
  • Isaburo Fujimoto
    • 1
  1. 1.Department of Field ResearchCenter for Adult DiseasesOsakaJapan
  2. 2.Osaka Red Cross Blood CenterOsakaJapan