Intensive Care Medicine

, Volume 8, Issue 5, pp 215–222

Disturbances of selected plasma proteins in hyperdynamic septic shock

Authors

  • J. Witte
    • Department of Surgery, Klinikum GroßhadernUniversity of Munich
  • M. Jochum
    • Department of Surgery, Klinikum GroßhadernUniversity of Munich
  • R. Scherer
    • Department of Experimental MedicineMax-Planck-Insitute for Biochemistry
  • W. Schramm
    • Department of Internal MedicineUniversity of Munich
  • K. Hochstrasser
    • Department of ENT-Diseases, Klinikum GroßhadernUniversity of Munich
  • H. Fritz
    • Department of Institute of Clinical Chemistry and Clinical BiochemistryUniversity of Munich
Original Articles

DOI: 10.1007/BF01694524

Cite this article as:
Witte, J., Jochum, M., Scherer, R. et al. Intensive Care Med (1982) 8: 215. doi:10.1007/BF01694524
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Abstract

This study was performed on patients (n=18) suffering from strictly defined hyperdynamic septic shock. Plasma factors (C-reactive protein, acid α1-glycoprotien, fibrinogen, fibrinopeptide A, fibrinogen-fibrin split products, factor XIII, antithrobin III, complement factors C3 and C4, inter-α-trypsin-inhibitor and α2-macroglobulin) measured during hyperdynamic septic shock were highly abnormal. The activation and consumption of clotting, fibrinolytic and complement factors due to system-specific proteinases (such as thrombokinase or plasminogen activators) seemed to be intensified by the nonspecific proteolytic activity of granulocytic proteinases probably released by the action of endotoxins. Possible therapeutic measures to maintain the endogeneous defence mechanism against enhanced proteolysis during septic shock are discussed.

Key words

Septic shockCoagulationFibrinolytic and complement systemsGranulocytic proteinasesNonspecific proteolysisProteinase inhibitors

Copyright information

© Springer-Verlag 1982