International Association of Endocrine Surgeons—Manuscripts Presented at the 33rd World Congress of the International Society of Surgery

World Journal of Surgery

, Volume 14, Issue 3, pp 393-398

First online:

Surgery for benign insulinoma: An international review

  • Matthias RothmundAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Lucio AngeliniAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , L. Michael BruntAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , John R. FarndonAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Glenn GeelhoedAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Dimitrie GramaAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Christian HerfarthAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Edwin L. KaplanAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
  • , Felix LargiaderAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Francesco MorinoAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Hans-Jürgen PeiperAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Charles ProyeAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Hans-Dietrich RöherAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Klaus RückertAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Fritz KümmerleAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Norman W. ThompsonAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic
    • , Jon A. van HeerdenAffiliated withDepartment of Surgery, University Hospital4th Department of SurgeryDepartment of Surgery, Washington UniversityDepartment of Surgery, The Royal Victoria Infirmary, Newcastle upon TyneDepartment of Surgery, The George Washington University Medical CenterDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of ChicagoDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, University of Michigan Medical CenterDepartment of Surgery, Mayo Clinic

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Abstract

In a multiinstitutional review, data on 396 patients with benign solitary or multiple insulinomas operated on in 15 centers were collected. In these 396 patients, 419 laparotomies (375 primary procedures and 44 reoperations) were performed. The rate of unnecessary laparotomies was 1.7%. Complications occurred after 132 operations (31.5%), requiring 27 reinterventions (6.4%). Ten (2%) patients died within 30 days of surgery. The success rate of first procedures in the centers was 94.9%. After reoperation, all but 2 (99.5%) of these patients were cured. The overall cure rate including those patients who had their primary operations elsewhere was 97.5%.

Résumé

Compilant les dossiers de 15 établissements internationaux, nous avons colligé les données concernant 396 patients présentant un insulinome bénin unique ou multiple, opérés. Chez ces 396 patients, 419 laparotomies (375 interventions de première intention et 44 reprises) ont été effectuées. Le taux de laparotomie inutile était de 1.7%. Des complications sont intervenues à la suite de 132 opérations (31.5%), nécessitant 27 réinterventions (6.4%). Dix (2%) patients sont morts dans les trente jours après l'acte chirurgical. Le taux de succès des interventions de première intention dans les centres de l'étude était de 94.9%. Après réinterventions, tous les patients sauf 2 (99.5%) ont été guéris. Le taux global de guérison, y compris les patients ayant été opérés une première fois ailleurs, était de 97.5%.

Resumen

En una revisión multiinstitucional se recolectaron los datos sobre 396 pacientes con insulinomas benignos solitarios o múltiples operados en 15 centros. En estos 396 pacientes se efectuaron 419 laparotomías (375 procedimientos primarios y 44 reoperaciones). Se registró una tasa de laparotomías innecesarias de 1.7%; se presentaron complicaciones después de 132 operaciones (31.5%), las cuales requirieron 27 reintervenciones (6.4%). Diez (2%) pacientes murieron dentro de los primeras 30 días después de la cirugía. La tasa de éxito del procedimiento primario realizado en estos centros fue 94.9%. Después de las reoperaciones la totalidad de los pacientes, menos 2 (99.5%), fueron curados. La tasa global de curación, incluyendo los que tuvieron su operación primaria por fuera de los centros del estudio, fue 97.5%.