International Journal of Colorectal Disease

, Volume 2, Issue 4, pp 208–213

Submucosal collagen changes in the normal colon and in diverticular disease


  • H. J. Thomson
    • Gastrointestinal UnitWestern General Hospital
  • A. Busuttil
    • Pathology DepartmentWestern General Hospital
  • M. A. Eastwood
    • Gastrointestinal UnitWestern General Hospital
  • A. N. Smith
    • Gastrointestinal UnitWestern General Hospital
  • R. A. Elton
    • Medical Statistics UnitUniversity of Edinburgh
Original Articles

DOI: 10.1007/BF01649507

Cite this article as:
Thomson, H.J., Busuttil, A., Eastwood, M.A. et al. Int J Colorect Dis (1987) 2: 208. doi:10.1007/BF01649507


Full thickness specimens of normal colon (n=15), and colon from patients with diverticular disease (n = 5) were obtained at operation or autopsy. In the isolated submucosa the ultrastructure of the constituent collagen fibres was examined by transmission electron microscopy. Collagen fibrils in the left colon become smaller (p < 0.001) and more tightly packed (p< 0.001) than those in the right colon with increasing age. This difference is accentuated in diverticular disease (p<0.01). Factors which contribute to the development of colonic diverticulosis, such as raised intraluminal pressure, may be responsible for premature change in submucosal structure.

Copyright information

© Springer-Verlag 1987