Klinische Wochenschrift

, Volume 69, Issue 18, pp 830–835

Differential patterns of PMN-elastase and type III procollagen peptide in knee joint effusions due to acute and chronic sports injuries

  • K. -A. Riel
  • M. Jochum
  • P. Bernett
  • H. Fritz
Originals

DOI: 10.1007/BF01649454

Cite this article as:
Riel, K.-., Jochum, M., Bernett, P. et al. Klin Wochenschr (1991) 69: 830. doi:10.1007/BF01649454
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Summary

In 38 traumatic knee joint effusions the proteolytic enzyme PMN-elastase (PMN-E) and the repair marker procollagen III aminoterminal peptide (PIIINP) were determined. According to the period between trauma and first aspiration of the effusion, the patients were divided into 3 groups. Group I (17 patients; period between trauma and first aspiration not longer than 72 hours) showed high concentrations of PMN-E (up to 5400 ng/ml) and low concentrations of PIIINP (<13 U/ml). Group II (11 patients; aspiration within 4 to 14 days) had mean PMN-E and PIIINP concentrations of 125.6 ng/ml and 52.1 U/ ml, respectively. In group III (10 patients, aspiration after 14 days) mean PMN-E concentration was 123.8 ng/ml and mean PIIINP concentration was 63.4 U/ml. Graphic depiction of PMN-E and PIIINP levels in each individual sample as a function of time between trauma and fluid collection revealed highly increasing PMN-E levels during the first 24 posttraumatic hours, followed by rapidly decreasing levels within 72 hours post trauma, and no change after the 4th posttraumatic day. In contrast, PIIINP increased continuously up to the first posttraumatic week and stayed at high levels up to 90 days (end of the observation period). The differential patterns of PMN-E and PIIINP concentration in knee joint effusions may be useful in estimating the period between trauma and first treatment (aspiration of effusion) and should, therefore, be helpful in detecting degenerative lesions, which seem to be characterized by low PMN-E concomitantly with high PIIINP levels.

Key words

Traumatic knee joint effusionPMN-elastaseType III procollagen peptide

Abbreviations

PMN-E

elastase from polymorphonuclear granulocytes

PIIINP

procollagen III aminoterminal peptide

α1PI

α1-proteinase inhibitor

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • K. -A. Riel
    • 1
  • M. Jochum
    • 2
  • P. Bernett
    • 1
  • H. Fritz
    • 2
  1. 1.Klinikum rechts der IsarKlinik und Poliklinik für Sportverletzungen der Technischen Universität MünchenDeutschland
  2. 2.Abteilung für Klinische Chemie und Klinische Biochemie in der Chirurgischen Klinik InnenstadtLudwig-Maximilians-Universität MünchenDeutschland