Distribution of synaptic ribbons in the developing organ of Corti
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Studies of synaptogenesis in the developing organ of Corti in the intact mouse and in culture indicate that the inner and outer hair cells contain three populations of synaptic ribbons, i.e. ribbons adjacent to nerve fibres, free intracellular ribbons and misplaced ribbons apposed to non-neuronal elements. Ribbons adjacent to nerve fibres can be further classified into: ribbons synaptically engaged, ribbons participating in formation of presynaptic complexes only and ribbons that are not engaged to the hair cell membrane. In the developing innervated cultures the ribbon distributions are similar to those in the normal animal. Inner and outer hair cells differ in distribution of the ribbons. In the inner hair cells the ribbons adjacent to the nerve fibres are dominant (over 90%) and most of them (88%) are synaptically engaged. In the outer hair cells the presynaptic ribbons dominate the population (up to 60%) during the first postnatal week when the cells acquire afferent synaptic connections. This stage is followed by a marked reduction in the number of all ribbons. In the intact animal the rapid decrease results in a relative increase of misplaced and free ribbons. These changes are presumably due to the loss of some of the afferents. In the denervated hair cells the distribution of ribbons indicated the presence of conspicuous scatter. In the areas of incomplete denervation, however, the ribbons are apposed to the preserved fibres. Despite denervation, most of the ribbons develop the entire presynaptic complex in apposition to non-neuronal structures.
The different populations of synaptic ribbons appear to reflect different stages in synapse formation. Possibly, the synaptic body originates in the interior of the hair cell and subsequently migrates to the cell membrane. In any case, a nerve fibre appears critical in influencing the location of the synaptic ribbon. At the apposition of the ribbon to the hair cell membrane, presynaptic densities are formed and the ribbon appears to become anchored. Typically, the nerve fibre membrane apposed to the presynaptic complex responds with the formation of postsynaptic densities.
- Becker, R. A. &Chambers, J. M. (1984) An Interactive Environment for Data Analysis and Graphics. Wadsworth advanced book program. Belmont, California.
- Benshalom, G. &Flock, A. (1980) Ultrastructure of synapses in the lateral line canal organ.Acta otolaryngologica 90, 161–74.
- Delaveuve, B. (1974) Mise en évidence d'altérations dans les cellules sensorielles des neuromasters du Xénope après section du nerf latéral. Etude ultrastructurale.Comptes Rendus l'Académie des Sciences 278, 1063–6.
- Denizot, J. P. &Libouban, S. (1985) New formation of sensory cells in the tuberous organ (electroreceptor) ofBrienomyrus niger (Mormyridae) induced by transection of afferent nerve.International Journal of Developmental Neuroscience 3, 323–30.
- Derbin, C. (1970) Effets de la section du nerf latéral sur les jonctions sensorineurales des ampoules de Lorenzini de la torpille,Torpedo marmorata. Journal de Microscopic 9, 119–26.
- Engström, H., Bergström, B. &Ades, H. W. (1972) Macula utriculi and macula sacculi in the squirrel monkey.Acta otolaryngologica Suppl.301, 72–126.
- Flock, Å., Jørgensen, M. &Russell, I. (1973) The physiology of individual hair cells and their synapses. InBasic Mechanisms in Hearing (edited byMøller, A. R.), pp. 273–306. New York, London: Academic Press.
- Ginzberg, R. D. &Gilula, N. B. (1980) Synaptogenesis in the vestibular sensory epithelium of the chick embryo.Journal of Neurocytology 9, 405–24.
- Gleisner, L. &Wersäll, J. (1975) Experimental studies on the nerve-sensory cell relationship during degeneration and regeneration in ampullar nerves of the frog labyrinth.Acta otolaryngologica Suppl.333, 1–28.
- Hirokawa, N. (1977) Disappearance of afferent and efferent nerve terminals in the inner ear of the chick embryo after chronic treatment with B-bungarotoxin.Journal of Cell Biology 73, 27–46.
- Hirokawa, N. (1978) Synaptogenesis in the basilar papilla of the chick.Journal of Neurocytology 7, 283–300.
- Jørgensen, J. M. &Flock, Å. (1976) Non-innervated sense organs of the lateral line: development in the regenerating tail of the salamanderAmbystoma mexicanum.Journal of Neurocytology 5, 33–41.
- Morrison, J. D. (1977) Electron microscopic studies of developing kitten retina.Journal of Physiology 273, 91–92P.
- Olney, J. W. (1968) An electron microscopic study of synapse formation, receptor outer segment development, and other aspects of developing mouse retina.Investigative Ophthalmology 7, 250–68.
- Pfenninger, K., Sandri, C., Akert, K. &Eugster, C. H. (1969) Contribution to the problem of structural organization of the presynaptic area.Brain Research 12, 10–18.
- Rebillard, M. &Pujol, R. (1983) Innervation of the chicken basilar papilla during its development.Acta otolaryngologica 96, 379–88.
- Shnerson, A., Devigne, C. &Pujol, R. (1982) Age-related changes in the C57BL/6J mouse cochlea. II. Ultrastructural findings.Developmental Brain Research 2, 77–88.
- Siegel, J. H. &Brownell, W. E. (1981) Presynaptic bodies in outer hair cells of the chinchilla organ of Corti.Brain Research 220, 188–93.
- Sobin, A. &Anniko, M. (1983) Embryonic development of the specific vestibular hair cell pathology in a strain of the waltzing guinea pig.Acta otolaryngologica 96, 397–405.
- Sobkowicz, H. M., Bereman, B. &Rose, J. E. (1975) Organotypic development of the organ of Corti in culture.Journal of Neurocytology 4, 543–72.
- Sobkowicz, H. M., Rose, J. E., Scott, G. L. &Holy, J. M. (1984) The ultra structure of the developing organ of Corti of the mouse in culture. InUltrastructural Atlas of the Inner Ear (edited byFriedmann, I. &Ballantyne, J.), pp. 61–97. London, Boston, Durban, Singapore, Sydney, Toronto, Wellington: Butterworths.
- Sobkowicz, H. M., Rose, J. E., Scott, G. E. &Slapnick, S. M. (1982) Ribbon synapses in the developing intact and cultured organ of Corti in the mouse.Journal of Neuroscience 2, 942–57.
- Tanaka, K. &Smith, C. A. (1978) Structure of the chicken's inner ear: SEM and TEM study.American Journal of Anatomy 153, 251–72.
- Thorn, L. (1975) Die entwicklung des cortischen organs beim meerschweinchen.Advances in Anatomy, Embryology, and Cell Biology 51, 7–97.
- Thorn, L., Schinko, I. &Wetzstein, R. (1972) Synaptic bar in the efferent part of a synapse in the organ of Corti.Experientia 28, 835.
- Thornhill, R. A. (1972) The development of the labyrinth of the lamprey (Lampetrafluviatilis Linn. 1758).Proceedings of the Royal Society of London, Series B 181, 175–98.
- Van De Water, T. R., Anniko, M., Nordemar, H. &Wersäll, J. (1977) Embryonic development of the sensory cells in macula utriculae of mouse, InInner Ear Biology (edited byPortmann, M. &Aran, J. M.), Vol. 68, pp. 25–35. Paris: INSERM.
- Weidman, T. A. &Kuwabara, T. (1968) Postnatal development of the rat retina. An electron microscopic study.Archives of Ophthalmology 79, 470–84.
- Whitehead, M. C. &Morest, D. K. (1985) The growth of cochlear fibers and the formation of their synaptic endings in the avian inner ear: a study with the electron microscope.Neuroscience 14, 277–300.
- Distribution of synaptic ribbons in the developing organ of Corti
Journal of Neurocytology
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