Variability of vertebral and femoral postmenopausal bone loss: A longitudinal study
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The rate of postmenopausal bone loss varies considerably between individuals and it has been suggested that about 1 in 3 women loses significant amount of bone mineral in the forearm. The rate of vertebral and femoral bone loss was determined by dual-energy X-ray absorptiometry throughout two consecutive 22-month periods, in 93 healthy women who had passed a natural menopause 6–60 months earlier. In all cases the bone changes were normally distributed, ranging from −6.9% to +2.8% per year in the spine and from −7% to +4.8% per year in the femur. No significant relationship was found between the two fractional rates of bone loss. When the women were stratified into three groups according to their individual rate of bone loss, we found that only 20%–47% retained their first classification during the second period of follow-up. In particular, less than 10% of the women showed a rapid rate of bone loss throughout the study. We conclude that spontaneous vertebral and femoral bone loss exhibit a great variability within the first postmenopausal years and that only a small minority of women sustain a fast rate of bone loss over several years. These results raise the question as to whether the evaluation of individual rates of bone loss at menopause might be useful in the identification of women at higher risk of osteoporosis.
- Smith DM, Norton JA, Khairi R, Johnston CC. The measurement of rates of mineral loss with aging. J Lab Clin Med 1976;87:882–92.
- Hui SL, Slemenda CW, Johnston CC. The contribution of bone loss to postmenopausal osteoporosis. Osteoporosis Int 1990;1:30–4
- Nordin BEC, Cleghorn DB, Chatterton BE, Morris HA, Need AG. A 5-year longitudinal study of forearm bone mass in 307 postmenopausal women. J Bone Miner Res 1993;8:1427–32.
- Ross PD, He YF, Davis JW, Epstein RS, Wasnich RD. Normal ranges for bone loss rates. Bone Miner 1994;26:169–80.
- Christiansen C, Riis BJ, Rodbro P. Prediction of rapid bone loss in postmenopausal women. Lancet 1987;1:1105–7.
- Hansen MA, Overgaard K, Riis BJ, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ 1991;303:961–4.
- Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C. Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture. A 15 year follow-up study. J Bone Miner Res 1995;10:S146.
- Christiansen C, Riis BJ, Dodbro P. Screening procedure for women at risk of developing postmenopausal osteoporosis. Osteoporosis int 1990;1:35–40.
- Pouillès JM, Trémollières F, Ribot C. The effect of menopause on longitudinal bone loss from the spine. Calcif Tissue Int 1993;52:340–3.
- Pouillès JM, Trémollières F, Todorovsky N, Ribot C. Precision and sensitivity of dual-energy X-ray absorptiometry in spinal osteoporosis. J Bone Miner Res 1991;6:997–1002.
- He YF, Davis JW, Ross PD, Wasnich RD. Declining bone loss rate variability with increasing follow-up time. Bone Miner 1993;21:119–28.
- Hassager C, Jensen SB, Gotfredsen A, Christiansen C. The impact of measurement error on the diagnostic value of bone mass measurements: theoretical considerations. Osteoporosis Int 1991;1:250–6.
- Nielsen SP, Munk-Jensen N, Obel EB, Barenholdt O. Prophylaxis of bone loss: long-term effects of continuous and sequential estrogen/progestin administration and identification of women at risk. In: Deluca HF, Mazess RB, editors. Osteoporosis: physiological basis, assessment, and treatment. Amsterdam: Elsevier, 1990:147–60.
- Pouillès JM, Trémollières F, Ribot C. Effect of menopause on femoral and vertebral bone loss. J Bone Miner Res 1995;10:1531–6.
- Smith DM, Khairi MRA, Johnston CC. The loss of bone mineral with aging and its relationship to ris of fracture. J Clin Invest 1975;56:311–8.
- Davis JW, Grove JS, Ross PD, Vogel JM, Wasnich RD. Relationship between bone mass and rates of bone change at appendicular measurement sites. J Bone Miner Res 1992;7:719–25.
- Van Hemert AM, Vandenbroucke JP, Hofman A, Valkenburg HA. Metacarpal bone loss in middle-aged women: “horse racing” in a 9-year population based follow-up study. J Clin Epidemiol 1990;43:579–88.
- Smith DM, Khairi MRA, Norton J, Johnston CC. Age and activity effects of rate of bone mineral loss. J Clin Invest 1976;58:716–21.
- Pouillès JM, Trémollières F, Ribot C. Influence of body weight changes on the rate of postmenopausal bone loss. Ann Endocrinol (Paris) 1995;56:585–9.
- Variability of vertebral and femoral postmenopausal bone loss: A longitudinal study
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