Journal of Cancer Research and Clinical Oncology

, Volume 116, Issue 5, pp 434–438

Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes

V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes
  • Hans -Dieter vom Orde
  • Herta Reile
  • Richard Müller
  • Ronald Gust
  • Günther Bernhardt
  • Thilo Spruß
  • Helmut Schönenberger
  • Thomas Burgemeister
  • Albrecht Mannschreck
Original Papers Experimental Oncology

DOI: 10.1007/BF01612989

Cite this article as:
vom Orde, H.D., Reile, H., Müller, R. et al. J Cancer Res Clin Oncol (1990) 116: 434. doi:10.1007/BF01612989

Summary

The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.

Key words

(R,R)- and (S,S)-[1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II)SynthesisMCF7 breast cancer cell lineP388 murine leukemia

Abbreviations

R,R/S,S

racemate

R,S

meso

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Hans -Dieter vom Orde
    • 1
  • Herta Reile
    • 1
  • Richard Müller
    • 1
  • Ronald Gust
    • 1
  • Günther Bernhardt
    • 1
  • Thilo Spruß
    • 1
  • Helmut Schönenberger
    • 1
  • Thomas Burgemeister
    • 2
  • Albrecht Mannschreck
    • 2
  1. 1.Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Sonderforschungsbereich 234 (SFB 234)Universität RegensburgRegensburgFederal Republic of Germany
  2. 2.Institut für Organische Chemie (SFB 234)Universität RegensburgRegensburgFederal Republic of Germany