Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes
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- vom Orde, H.D., Reile, H., Müller, R. et al. J Cancer Res Clin Oncol (1990) 116: 434. doi:10.1007/BF01612989
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The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.
Key words(R,R)- and (S,S)-[1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II)SynthesisMCF7 breast cancer cell lineP388 murine leukemia