Increased resistance amongStaphylococcus epidermidis isolates in a large teaching hospital over a 12-year period

  • O. Lyytikäinen
  • M. Vaara
  • E. Järviluoma
  • K. Rosenqvist
  • L. Tiittanen
  • V. Valtonen
Article

DOI: 10.1007/BF01591486

Cite this article as:
Lyytikäinen, O., Vaara, M., Järviluoma, E. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1996) 15: 133. doi:10.1007/BF01591486

Abstract

The prevalence of drug resistance among clinically significant blood isolates ofStaphylococcus epidermidis (n=464) and consumption of antibiotics at a tertiary care teaching hospital (Meilahti Hospital, Helsinki) were analysed for the period 1983–1994. Resistance to methicillin increased from 28 to 77%. Simultaneously, usage of thirdgeneration cephalosporins increased nearly sevenfold (from 8.6 kg/ to 56.4 kg/year). A significant correlation was found between percentages of methicillin resistance and usage of penicillinase-stable β-lactam agents, including cloxacillin, imipenem, and first-, second-, and third-generation cephalosporins (r=0.737, p<0.0062). The increase in ciprofloxacin resistance occurred soon after the introduction of ciprofloxacin. Moreover, there was a remarkable increase in resistance to fusidic acid (from 10 to 40%) and rifampin (from 0 to 23%) despite the low usage of these agents. Overall, the rate of multiply resistant isolates roughly tripled (from 20 to 71 %) and, by 1994, the frequency of isolates susceptible to vancomycin only was as high as 11%, which remarkably limits options for therapy.

Copyright information

© MMV Medizin Verlag GmbH Munchen 1996

Authors and Affiliations

  • O. Lyytikäinen
    • 1
    • 4
  • M. Vaara
    • 3
  • E. Järviluoma
    • 2
  • K. Rosenqvist
    • 2
  • L. Tiittanen
    • 1
  • V. Valtonen
    • 1
  1. 1.Department of Medicine, Division of Infectious DiseasesHelsinki University Central HospitalHelsinkiFinland
  2. 2.Hospital PharmacyHelsinki University Central HospitalHelsinkiFinland
  3. 3.Department of Bacteriology and ImmunologyHelsinki UniversityHelsinkiFinland
  4. 4.Department of Infection EpidemiologyNational Public Health InstituteHelsinkiFinland

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