Increased resistance amongStaphylococcus epidermidis isolates in a large teaching hospital over a 12-year period
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- Lyytikäinen, O., Vaara, M., Järviluoma, E. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1996) 15: 133. doi:10.1007/BF01591486
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The prevalence of drug resistance among clinically significant blood isolates ofStaphylococcus epidermidis (n=464) and consumption of antibiotics at a tertiary care teaching hospital (Meilahti Hospital, Helsinki) were analysed for the period 1983–1994. Resistance to methicillin increased from 28 to 77%. Simultaneously, usage of thirdgeneration cephalosporins increased nearly sevenfold (from 8.6 kg/ to 56.4 kg/year). A significant correlation was found between percentages of methicillin resistance and usage of penicillinase-stable β-lactam agents, including cloxacillin, imipenem, and first-, second-, and third-generation cephalosporins (r=0.737, p<0.0062). The increase in ciprofloxacin resistance occurred soon after the introduction of ciprofloxacin. Moreover, there was a remarkable increase in resistance to fusidic acid (from 10 to 40%) and rifampin (from 0 to 23%) despite the low usage of these agents. Overall, the rate of multiply resistant isolates roughly tripled (from 20 to 71 %) and, by 1994, the frequency of isolates susceptible to vancomycin only was as high as 11%, which remarkably limits options for therapy.