, Volume 3, Issue 1, pp 381–391

The antibody response during amphibian ontogeny

  • L. Du Pasquier
  • J. Haimovich

DOI: 10.1007/BF01576969

Cite this article as:
Du Pasquier, L. & Haimovich, J. Immunogenetics (1976) 3: 381. doi:10.1007/BF01576969


The maturation of the anti DNP-response in adult and larval amphibians has been compared in two species of anurans,Rana catesbeiana andXenopus laevis. IgM responses were very similar in larvae and adults of both species. Specific IgG antibody synthesis, studied inRana catesbeiana only, was not obvious in larval primary response but was easily detectable in adults. Although metamorphosis results in profound changes in the lymphoid system associated with the apparent acquisition of self tolerance to new antigens, immunological memory of antigens injected during larval life ofRana andXenopus persists after the metamorphosis period.

Copyright information

© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • L. Du Pasquier
    • 1
  • J. Haimovich
    • 2
  1. 1.Basel Institute for ImmunologyBasel 5Switzerland
  2. 2.The Weizmann Institute of ScienceRehovotIsrael