Journal of Industrial Microbiology

, Volume 16, Issue 2, pp 134–143

Cyclic peptides and depsipeptides from cyanobacteria: A review

Authors

  • R E Moore
    • Department of ChemistryUniversity of Hawaii
Article

DOI: 10.1007/BF01570074

Cite this article as:
Moore, R.E. Journal of Industrial Microbiology (1996) 16: 134. doi:10.1007/BF01570074

Abstract

An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates. Most of these cyclic peptides and depsipeptides, such as the microcystins and the lyngbyatoxins, will probably only be useful as biochemical research tools. A few, however, have the potential for development into useful commercial products. For example, cryptophycin-1, a novel inhibitor of microtubule assembly fromNostoc sp GSV 224, shows impressive activity against a broad spectrum of solid tumors implanted in mice, including multidrug-resistant ones, and majusculamide C, a microfilament-depolymerizing agent fromLyngbya majuscula, shows potent fungicidal activity and may have use in the treatment of resistant fungal-induced diseases of domestic plants and agricultural crops.

Keywords

cyanobacterianatural productshepatotoxinsfungicidesantitumor agentsenzyme inhibitors

Copyright information

© Society for Industrial Microbiology 1996