, Volume 12, Issue 3, pp 163-167

Virulence ofAeromonas species as assessed through mouse lethality studies

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The relative virulence of 32Aeromonas isolates, primarily of clinical origin, were evaluated for mouse lethality by intraperitoneal inoculation of 107 CFU into albino mice. Three categories could be distinguished on the basis of this assay, including a highly virulent group (80%–100% mortality), a low to moderate virulence category (20%–60% mortality), and strains that were completely avirulent. Of theA. sobria isolates tested, 82% fell into the highly virulent category (P<0.005), whereasA. hydrophila strains were intermediate in virulence potential, andA. caviae strains studied were avirulent. There was no apparent correlation between highly virulentAeromonas isolates and phenotypes associated with enterotoxigenicity, hemolytic activity, cytotoxin production, or serum resistance; this suggests that a cell surface property may be important in mouse pathogenicity. The results of these studies indicate that mouse lethality assays may be an appropriate model for the study of invasive disease clinically produced byA. sobria andA. hydrophila.