Short Communication

Chromosome Research

, Volume 2, Issue 3, pp 255-256

Localization of uridine monophosphate synthase (UMPS) gene to river buffalo chromosomes by FISH

  • L. IannuzziAffiliated withNational Research Council (CNR), I.A.B.B.A.M.
  • , G. P. Di MeoAffiliated withNational Research Council (CNR), I.A.B.B.A.M.
  • , A. M. RyanAffiliated withDepartment of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and Technology, Texas A & M University
  • , D. S. GallagherAffiliated withDepartment of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and Technology, Texas A & M University
  • , L. FerraraAffiliated withNational Research Council (CNR), I.A.B.B.A.M.
  • , J. E. WomackAffiliated withDepartment of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and Technology, Texas A & M University

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Abstract

Uridine monophosphate synthase plays an important role in pyrimidine synthesis, converting orotic acid to uridine 5′ monophosphate. In cattle,UMPS deficiency is inherited as a monogenic autosomal recessive trait. While heterozygous carriers are phenotypically normal, homozygotes are lethalin utero (Shankset al. 1992).UMPS has been mapped to human chromosome 3q13 (Qumsiyehet al. 1989), sheep chromosome 1q (Burkinet al. 1993) and cattle chromosome 1q31 (Ryanet al. 1994). In the present study we used a cattle genomic probe to localizeUMPS to river buffalo chromosomes by fluorescencein situ hybridization.

Key words

Bubalus bubalis chromosomes FISH river buffalo UMPS