Chromosome Research

, Volume 2, Issue 3, pp 255–256

Localization of uridine monophosphate synthase (UMPS) gene to river buffalo chromosomes by FISH

Authors

  • L. Iannuzzi
    • National Research Council (CNR)I.A.B.B.A.M.
  • G. P. Di Meo
    • National Research Council (CNR)I.A.B.B.A.M.
  • A. M. Ryan
    • Department of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and TechnologyTexas A & M University
  • D. S. Gallagher
    • Department of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and TechnologyTexas A & M University
  • L. Ferrara
    • National Research Council (CNR)I.A.B.B.A.M.
  • J. E. Womack
    • Department of Veterinary Pathobiology and Center for Animal Genetics, Institute of Biosciences and TechnologyTexas A & M University
Short Communication

DOI: 10.1007/BF01553326

Cite this article as:
Iannuzzi, L., Di Meo, G.P., Ryan, A.M. et al. Chromosome Res (1994) 2: 255. doi:10.1007/BF01553326

Abstract

Uridine monophosphate synthase plays an important role in pyrimidine synthesis, converting orotic acid to uridine 5′ monophosphate. In cattle,UMPS deficiency is inherited as a monogenic autosomal recessive trait. While heterozygous carriers are phenotypically normal, homozygotes are lethalin utero (Shankset al. 1992).UMPS has been mapped to human chromosome 3q13 (Qumsiyehet al. 1989), sheep chromosome 1q (Burkinet al. 1993) and cattle chromosome 1q31 (Ryanet al. 1994). In the present study we used a cattle genomic probe to localizeUMPS to river buffalo chromosomes by fluorescencein situ hybridization.

Key words

Bubalus bubalischromosomesFISHriver buffaloUMPS

Copyright information

© Rapid Communications of Oxford Ltd 1994