Archives of Sexual Behavior

, Volume 17, Issue 1, pp 87–98

Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration


  • L. Rousseau
    • Human Sexuality ProgramLaval University Medical School
  • A. Dupont
    • Department of Molecular EndocrinologyLaval University Medical Center
  • F. Labrie
    • Department of Molecular EndocrinologyLaval University Medical Center
  • M. Couture
    • Human Sexuality ProgramLaval University Medical School
    • Sex Offenders ClinicRobert Giffard Hospital Center

DOI: 10.1007/BF01542054

Cite this article as:
Rousseau, L., Dupont, A., Labrie, F. et al. Arch Sex Behav (1988) 17: 87. doi:10.1007/BF01542054


The results of a written questionnaire with 44 patients (pilot study) indicated that before the beginning of treatment for advanced prostatic cancer, most subjects had an active sexual life, as illustrated by a normal erotic imagery, an adequate sexual desire and a normal frequency of intercourse. More than three-quarters (80%) of subjects had at least one coitus a week. Slightly more than 50% were able to easily achieve an erection by erotic imagery or by a preferred sexual fantasy; 50% never experienced erectile problems. When compared with their previous sexual functioning, 70% of subjects noticed during the antiandrogenic treatment a major reduction in their interest for sexual intercourse which was maintained in only 18% of patients. It became impossible for 57% to induce an erection by erotic imagery. However, 19% claimed an ability to maintain an erection during sexual activity, as compared to 56% before treatment, but erections usually lacked full rigidity. Twenty-two percent of patients mentioned having nocturnal or morning erections. Despite this dramatic decrease in sexual activity in most patients, complete antiandrogen blockade left sexual activity in approximately 20% of patients. Due to the treatment's excellent tolerance, the findings suggest that such combined androgen blockade could be beneficial for the treatment of sex offenders.

Key words

sexual behavior prostatic cancer medical castration orchiectomy antiandrogen LHRH agonist sexual desire intercourse erectile problems sex offenders

Copyright information

© Plenum Publishing Corporation 1988