, Volume 35, Issue 12, pp 1500-1504

Effects of cisapride on gastrointestinal transit in healthy humans

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Abstract

It was the aim of this study to assess the effects of cisapride on gastrointestinal transit of solids in healthy humans. Twelve men received cisapride 10 mg or placebo orally four times a day in random, double-blind, crossover fashion. Transit measurements were performed with a new gamma camera technique. Cisapride reduced mean gastric emptying time of99mTc-labeled cellulose fiber {0.77 (0.69–1.12) hr [median (range)] vs 0.98 (0.63–1.95) hr; P<0.05 and 1- to 2- mm111In- labeled plastic particles [1.08 (0.50–1.42) hr vs 1.69 (0.59–3.03) hr; P<0.01]. Cisapride also decreased mean small intestinal transit time of cellulose fiber [2.11 (0.80–5.08) hr vs 2.82 (0.78–7.12) hr; P<0.05] and plastic particles [2.06 (1.13–5.13) hr vs 2.64 (1.18–7.04) hr; P<0.05]. However, cisapride increased mean large intestinal transit time of plastic particles [31 (13–75) hr vs 23 (12–36) hr; P<0.05]. In conclusion, oral cisapride 10 mg four times a day accelerates gastric emptying and small intestinal transit whereas this dose of cisapride seems to delay large intestinal transit of solids in healthy humans.

Tablets of cisapride and placebo were provided by Janssen Pharmaceutica, Beersee, Belgium.