Digestive Diseases and Sciences

, Volume 34, Issue 5, pp 773–780

Intestinal infections in patients with acquired immunodeficiency syndrome

A prospective study in 132 Patients
  • E. René
  • C. Marche
  • B. Regnier
  • A. G. Saimot
  • J. L. Vilde
  • C. Perrone
  • C. Michon
  • M. Wolf
  • Th. Chevalier
  • Th. Vallot
  • F. Brun-Vesinet
  • B. Pangon
  • A. M. Deluol
  • F. Camus
  • C. Roze
  • J. P. Pignon
  • M. Mignon
  • S. Bonfils
Original Articles

DOI: 10.1007/BF01540353

Cite this article as:
René, E., Marche, C., Regnier, B. et al. Digest Dis Sci (1989) 34: 773. doi:10.1007/BF01540353

Abstract

We studied prospectively 132 patients with acquired immunodeficiency syndrome to define the spectrum of enteric pathogens during this disease, with special reference to the correlation between the lesions, the infections, and the symptoms. Forty-four percent of the patients harbored at least one enteric pathogen: the most frequently recovered were Cryptosporidium (28), cytomegalovirus (16), Entamoeba histolytica (13), Giardia lamblia (9), and Mycobacterium avium intracellulare (7). Patients harboring pathogens were more likely to be diarrheics (69%) than patients without a pathogen (38%; P=0.01) and more likely to have endoscopic lesions (29%) than patients without a pathogen (4%; P<0.001). The most common pathogen associated with diarrhea was Cryptosporidium. Cytomegalovirus, Entamoeba histolytica, and Salmonella typhimurium were each significantly associated with endoscopic lesions. Patients with cytomegalovirus infection tended to have a greater incidence of ulcer than patients without cytomegalovirus infection. Stool analysis diagnosed 61% of the infections, while endoscopy diagnosed 44%. Seven percent were recognized by stool analysis and endoscopy. When considering the 24 patients in whom accurate diagnosis warranted endoscopic biopsies, stool examination alone would have given an incomplete diagnosis in 14 patients (due to the presence of polyinfection). The frequency of inaccurate diagnosis of infection by stool determination alone, plus the development of new antiviral agents that suppress cytomegalovirus, may favor the earlier application of endoscopic evaluation in these patients.

Key words

AIDS intestinal infections endoscopy diarrhea 

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • E. René
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • C. Marche
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • B. Regnier
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • A. G. Saimot
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • J. L. Vilde
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • C. Perrone
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • C. Michon
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • M. Wolf
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • Th. Chevalier
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • Th. Vallot
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • F. Brun-Vesinet
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • B. Pangon
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • A. M. Deluol
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • F. Camus
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • C. Roze
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • J. P. Pignon
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • M. Mignon
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • S. Bonfils
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  1. 1.Service de GastroentérologieHôpital BichatParis Cedex 18France
  2. 2.Laboratory of Pathology, Intensive Care Unit, Department of Infectious DiseaseClaude-Bernard HospitalParis
  3. 3.Laboratory of VirologyClaude-Bernard HospitalParis
  4. 4.Laboratory of BacteriologyClaude-Bernard HospitalParis
  5. 5.Laboratory of ParasitologyClaude-Bernard HospitalParis
  6. 6.Faculty of Medicine Xavier BichatINSERM U239Paris
  7. 7.Department of Medical StatisticsPr. Flamant, Institut Gustave RoussyVillejuif CedexFrance

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