Original Articles

Digestive Diseases and Sciences

, Volume 34, Issue 5, pp 754-757

First online:

Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation

  • Eran GoldinAffiliated withDepartment of Gastroenterology, Hadassah University Hospital, Hebrew University Hadassah Medical SchoolDepartment of Biological Chemistry, The Hebrew University
  • , Fanny KarmeliAffiliated withDepartment of Gastroenterology, Hadassah University Hospital, Hebrew University Hadassah Medical SchoolDepartment of Biological Chemistry, The Hebrew University
  • , ZVI SelingerAffiliated withDepartment of Gastroenterology, Hadassah University Hospital, Hebrew University Hadassah Medical SchoolDepartment of Biological Chemistry, The Hebrew University
  • , Daniel RachmilewitzAffiliated withDepartment of Gastroenterology, Hadassah University Hospital, Hebrew University Hadassah Medical SchoolDepartment of Biological Chemistry, The Hebrew University

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Abstract

Substance P content was determined by radioimmunoassay in colonic mucosa from 24 patients with chronic severe constipation, 16 with active ulcerative colitis, and 28 normal controls. In patients with chronic severe constipation, the mean concentration of substance P (19.9±8.2 pg/mg) was significantly lower than in normal subjects (71±18 pg/mg). In patients with ulcerative colitis, colonic substance P concentration in inflamed mucosa (170±46 pg/mg) was significantly higher than its levels in normal subjects. Substance P may therefore have a role in the pathogenesis of clinical conditions associated with diarrhea and constipation.

Key words

substance P ulcerative colitis constipation