Digestive Diseases and Sciences

, Volume 34, Issue 11, pp 1730–1738

Lymphocytic (microscopic) colitis

Clinicopathologic study of 18 patients and comparison to collagenous colitis

Authors

  • Francis M. Giardiello
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Audrey J. Lazenby
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Theodore M. Bayless
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Edward J. Levine
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Wilma B. Bias
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Paul W. Ladenson
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • David F. Hutcheon
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • Nancy L. Derevjanik
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
  • John H. Yardley
    • Department of Medicine, Divisions of Gastroenterology and EndocrinologyThe Johns Hopkins University School of Medicine
    • The Departments of Pathology, Surgery and EpidemiologyThe Johns Hopkins University School of Medicine
Original Articles

DOI: 10.1007/BF01540051

Cite this article as:
Giardiello, F.M., Lazenby, A.J., Bayless, T.M. et al. Digest Dis Sci (1989) 34: 1730. doi:10.1007/BF01540051

Abstract

Lymphocytic colitis, formerly called microscopic colitis, is a clinicopathologic syndrome with chronic watery diarrhea and diffuse mucosal inflammatory changes with prominent intraepithelial lymphocytes. The 18 lymphocytic colitis patients studied presented with chronic watery diarrhea at a mean age of 53.8±17 years (±1 SD). Roentgenographic, endoscopic, and culture data were not diagnostic. In patients tested, there was a high prevalence of arthritis (82%) and autoantibodies (50%) but no increase in frequency of histocompatibility antigens associated with well-defined autoimmune disease (DR3, B8). Lymphocytic colitis patients were compared to 21 patients with collagenous colitis. Similarities included age, symptomatology, and nondiagnostic radiographic and endoscopic studies. However, the sex distribution was statistically different, with an equal male-to-female ratio in lymphocytic colitis and female predominance (80%) in collagenous colitis. Other differences included dissimilar histocompatibility phenotypes and collagen band on biopsies of collagenous but not lymphocytic colitis. These findings suggest that lymphocytic and collagenous colitis may be related yet distinct disorders.

Key words

microscopic colitislymphocytic colitiscollagenous colitisautoimmune

Copyright information

© Plenum Publishing Corporation 1989