Digestive Diseases and Sciences

, Volume 33, Supplement 3, pp 65S–70S

Role of inflammatory mediators in colonic smooth muscle function in ulcerative colitis

  • W. J. SnapeJr
  • H. W. Kao
Mediators of Inflammatory Bowel Disease

DOI: 10.1007/BF01538133

Cite this article as:
Snape, W.J. & Kao, H.W. Digest Dis Sci (1988) 33(Suppl 3): 65S. doi:10.1007/BF01538133

Abstract

Patients with ulcerative colitis have a decrease in colonic motility which may increase their diarrheal symptoms. Studies in patients with ulcerative colitis showed that the postprandial spike response was slightly decreased and the intraluminal pressure response was absent. In vitro studies showed that the circular smooth muscle, obtained from patients with ulcerative colitis or from a rabbit model of experimental colitis, generated decreased force compared to muscle not associated with mucosal inflammation. The decrease in muscle contraction was observed with bethanechol stimulation or electrical field stimulation. Since the response to an increased extracellular concentration of potassium ([K+]0) was also diminished, the decreased response appears to be caused by an abnormality in the intrinsic contractile mechanism of colonic smooth muscle. Further studies are necessary to determine if metabolic abnormalities are present in the colonic muscle in patients with colitis.

Key words

experimental colitis electrical field stimulation bethanechol 

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • W. J. SnapeJr
    • 1
    • 2
  • H. W. Kao
    • 1
    • 2
  1. 1.Harbor-UCLA Medical CenterTorrance
  2. 2.Inflammatory Bowel Disease CenterTorrance

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