Digestive Diseases and Sciences

, Volume 34, Issue 8, pp 1185–1192

Cyclic motility in canine colon: Responses to feeding and perfusion

  • Bernard Flourie
  • Sidney Phillips
  • Harry RichterIII
  • Fernando Azpiroz
Original Articles

DOI: 10.1007/BF01537266

Cite this article as:
Flourie, B., Phillips, S., Richter, H. et al. Digest Dis Sci (1989) 34: 1185. doi:10.1007/BF01537266

Abstract

To further characterize colonic motility in the dog and to examine the effects of intraluminal contents, motor activity in conscious animals was recorded by perfused intraluminal catheters. Animals were studied first with the bowel intact and, later, the colon was fashioned into an isolated loop. In the fasting state, cycles of motility recurred approximately each 30 min. These consisted of sequences of phasic contractions (bursts) that migrated variable distances in either direction; stationary bursts were also recorded. The fasting patterns recorded from intact bowel and isolated loops were not different. Feeding increased colonic motility, and the mean periodicity of cyclic bursts was reduced significantly to approximately 20 min. Moreover, differences were observed between intact bowel and isolated loops in the postprandial period. Diversion of chyme from the colon significantly reduced the motor response to food, but only in the late (2– 4 hr) postprandial period, when the less frequent, fasting cycle returned to the loops. Perfusion of isolated loops with chyme or saline reestablished the postprandial pattern seen in intact bowel. The results suggest that the volume, but not the composition, of luminal contents modify postprandial motility in the canine colon. Additional experiments confirmed that, in particular, volatile fatty acids were probably not important determinants of colonic motility in the dog.

Key words

canine coloncyclic motilityresponse to foodcolonic transit

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Bernard Flourie
    • 1
  • Sidney Phillips
    • 1
  • Harry RichterIII
    • 1
  • Fernando Azpiroz
    • 1
  1. 1.Gastroenterology UnitMayo ClinicRochester