Digestive Diseases and Sciences

, Volume 35, Issue 8, pp 984–992

Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat

Role of glycoprivic response
  • Koji Takeuchi
  • Megumu Okada
  • Hiromichi Niida
  • Susumu Okabe
Original Articles

DOI: 10.1007/BF01537247

Cite this article as:
Takeuchi, K., Okada, M., Niida, H. et al. Digest Dis Sci (1990) 35: 984. doi:10.1007/BF01537247

Abstract

Pathogenesis of indomethacin-induced gastric lesions was investigated in the rat by measuring lesions, gastric motility, and terminal blood glucose levels and correlating them with each other. Subcutaneously administered indomethacin (3–25 mg/kg) dose-dependently produced lesions in the stomach with concomitant gastric hypermotility and reduction of blood glucose levels. When the lesion score and the motility were plotted against terminal glucose levels, a highly significant relationship was found among these three factors (P < 0.01). Gastric lesions and hypermotility induced by indomethacin (25 mg/kg) were suppressed significantly by 16,16-dmPGE2 (10 Μg/kg) with no effect on the glucose levels, while intravenous infusion of glucose (25% w/w, 1.4 ml/hr) prevented these responses and restored the reduced glucose levels above the basal values. In addition, both 16,16-dmPGE2 and glucose infusion afforded a significant protection against gastric lesions induced by indomethacin even in the acid-perfused stomach (150 mM HCl). These results confirmed gastric hypermotility as a key element in the pathogenesis of indomethacin-induced lesions and further suggested that indomethacin may sensitize gastric contractility through glycoprivic receptors by inducing hypoglycemia and PG deficiency.

Key words

indomethacingastric lesiongastric motilityblood glucoseglycoprivic response

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Koji Takeuchi
    • 1
  • Megumu Okada
    • 1
  • Hiromichi Niida
    • 1
  • Susumu Okabe
    • 1
  1. 1.Department of Applied PharmacologyKyoto Pharmaceutical UniversityKyotoJapan