Digestive Diseases and Sciences

, Volume 33, Issue 11, pp 1345–1352

Diffuse excess mucosal collagen in rectal biopsies facilitates differential diagnosis of solitary rectal ulcer syndrome from other inflammatory bowel diseases

Authors

  • Douglas S. Levine
    • Division of Gastroenterology, Departments of Medicine and PathologyUniversity of Washington
  • Christina M. Surawicz
    • Division of Gastroenterology, Departments of Medicine and PathologyUniversity of Washington
  • Terese N. Ajer
    • Division of Gastroenterology, Departments of Medicine and PathologyUniversity of Washington
  • Patrick J. Dean
    • Division of Gastroenterology, Departments of Medicine and PathologyUniversity of Washington
  • Cyrus E. Rubin
    • Division of Gastroenterology, Departments of Medicine and PathologyUniversity of Washington
Original Articles

DOI: 10.1007/BF01536986

Cite this article as:
Levine, D.S., Surawicz, C.M., Ajer, T.N. et al. Digest Dis Sci (1988) 33: 1345. doi:10.1007/BF01536986

Abstract

Solitary rectal ulcer syndrome (SRUS) is sufficiently uncommon that the clinician or general pathologist may lack familiarity with the disorder and may confuse it with other inflammatory bowel diseases. To evaluate the role of collagen staining in facilitating the differential diagnosis of SRUS, an initial open review was undertaken on 1672 consecutive patients whose 4780 colorectal biopsies were stained with H&E with added saffron to demonstrate collagen. Excess mucosal collagen was present in 39 (2.3%) of these patients. Twenty patients with a diffuse excess of mucosal collagen in biopsies from rectal ulcer margins or from otherwise abnormal rectal mucosa had SRUS; in the remaining 19 patients, excess mucosal collagen was focal (seven ischemic colitis, five collagenous colitis, three adenocarcinoma, and four chronic idiopathic ulcerative colitis). Diffuse excess mucosal collagen never was seen in idiopathic inflammatory bowel disease (128 Crohn's colitis and 446 ulcerative colitis). Blinded reviews then were performed on rectal biopsies from 33 patients with a variety of diagnoses (14 SRUS and 19 controls). Diffuse excess collagen by saffron staining was consistently observed in SRUS but was absent in all 19 controls. Additional blinded reviews were carried out because the collagen staining pattern in ischemic colitis, although focal, could potentially be confused with SRUS. It was possible to differentiate these two diseases blindly from one another by using additional histologic criteria (14 SRUS and 12 ischemic colitis). We conclude that the demonstration of a diffuse excess of mucosal collagen in rectal biopsies facilitates the diagnosis of SRUS and differentiates it from idiopathic ulcerative colitis and Crohn's disease, with which SRUS is often confused, and other inflammatory bowel diseases.

Key words

colitis cystica profundacollagen stainconnective tissue stainCrohn's colitisidiopathic proctitisidiopathic ulcerative colitisinflammatory bowel diseaseischemic colitisrectal mucosal fibrosisrectal prolapsesolitary rectal ulcer syndrome

Copyright information

© Plenum Publishing Corporation 1988