Digestive Diseases and Sciences

, Volume 34, Issue 4, pp 612–616

Intravenous calcitonin gene-related peptide stimulates net water secretion in rat colonin Vivo

  • R. K. Rolston
  • M. A. Ghatei
  • P. K. Mulderry
  • S. R. Bloom
Original Articles

DOI: 10.1007/BF01536340

Cite this article as:
Rolston, R.K., Ghatei, M.A., Mulderry, P.K. et al. Digest Dis Sci (1989) 34: 612. doi:10.1007/BF01536340

Abstract

We have studied the effect of exogenous calcitonin gene-related peptide on net fluxes of water and electrolytes in the rat small and large intestine. In ligated intestinal loops, intravenous calcitonin gene-related peptide (CGRP) induced colonic fluid secretion but had no effect on the small intestine. Subsequently, using a single-pass perfusion technique, we observed an immediate dose-dependent secretion of water by the rat colon upon intravenous administration of CGRP. Net secretion of sodium, potassium, and chloride were also raised. The implications of these observations for the possible involvement of high circulation concentrations of CGRP in the watery diarrhea syndrome accompanying medullary thyroid carcinoma are discussed.

Key words

CGRPcolonic secretionperfusion

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • R. K. Rolston
    • 1
  • M. A. Ghatei
    • 1
  • P. K. Mulderry
    • 1
  • S. R. Bloom
    • 1
  1. 1.Department of Medicine, 2nd Floor Francis Fraser Laboratory, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK