Digestive Diseases and Sciences

, Volume 33, Issue 12, pp 1544–1548

Effect of aging on gastric acid secretion, serum gastrin, and antral gastrin content in rats

Authors

  • Talaat Khalil
    • Department of SurgeryThe University of Texas Medical Branch
  • Pomila Singh
    • Department of SurgeryThe University of Texas Medical Branch
  • Masaki Fujimura
    • Department of SurgeryThe University of Texas Medical Branch
    • Second Department of SurgeryShiga University of Medical Science
  • Courtney M. TownsendJr
    • Department of SurgeryThe University of Texas Medical Branch
  • George H. GreeleyJr
    • Department of SurgeryThe University of Texas Medical Branch
  • James C. Thompson
    • Department of SurgeryThe University of Texas Medical Branch
Original Articles

DOI: 10.1007/BF01535944

Cite this article as:
Khalil, T., Singh, P., Fujimura, M. et al. Digest Dis Sci (1988) 33: 1544. doi:10.1007/BF01535944

Abstract

The purpose of this study was to characterize the effects of aging on gastric acid secretion and on serum and antral concentrations of gastrin in rats. Young and old Fischer 344 rats were prepared with gastric fistulas. Twenty-four hours after surgery, graded doses of human synthetic gastrin-17 (SHG-17) (2, 5, 10, 20, and 40 μg/kg) were given intravenously in random order. Gastric secretions were collected for gastric acid measurement before and at 15-min intervals after each dose of gastrin. In a separate study, blood was collected and the stomachs were removed for antral gastrin extraction from fed young and old rats. Serum and antral gastrin was measured by radioimmunoassay. The basal and gastrin-stimulated acid secretions were significantly decreased in aged rats compared to the young rats. The basal acid output was 0.4±0.2 μeq/15 min in the aged rats and 1.5±0.5 μeq/15 min in the young. The maximal acid output stimulated by gastrin was 11.1±1.8 μeq/15 min in the aged rats and 24.2±2.8 μeq/15 min in the young. Both serum and antral concentrations of gastrin were significantly decreased in aged rats. Serum gastrin concentration was 114.8±7.4pg/ml in the aged rats and 192.0±14.4 pg/ml in the young. Antral gastrin concentration was 3.9±0.5 μg/g tissue in the aged rats, which was significantly less than the concentration in the young (6.5±0.4 μg/g tissue). Antral gastrin content did not change with aging. Gastric acid secretion in aged rats is significantly decreased compared to the young in both the basal condition and in response to fixed doses of exogenous gastrin. Diminished concentrations of circulating gastrin may well be responsible, at least in part, for the diminished acid secretion in the aged rats.

Key words

aginggastric secretiongastrinrats

Copyright information

© Plenum Publishing Corporation 1988