Original Articles

Digestive Diseases and Sciences

, Volume 33, Issue 3, pp 263-269

First online:

Hepatitis B vaccination

Response of alcoholic with and without liver injury
  • Charles MendenhallAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Gary A. RoselleAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Lisa A. LybeckerAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Laine E. MarshallAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Charles J. GrossmanAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Steven A. MyreAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , Robert E. WeesnerAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University
  • , David D. MorganAffiliated withVA Medical Center, Hepatic Research LaboratoryDepartment of Medicine, The College of PharmacyDepartment of Physiology and Biophysics, University of Cincinnati Medical CenterDepartment of Biological Sciences, Xavier University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Alcoholics are at risk to develop hepatitis B infections, chronic active hepatitis, and even hepatoma. Hence, immunization with hepatitis B vaccine is recommended. However, immune abnormalities may coexist which alter their responsiveness to vaccination. This study compares the immune response to this vaccine in controls (group I), alcoholics without overt liver disease (group II), and alcoholics with clinical liver disease (group III). By the seventh month after the initial vaccination, 89% in group I, 70% in group II, and 18% in group III had a response >36 RIA units. The magnitude of the response was significantly different in groups I, II, and III (19,456 vs 8,326 vs 153 RIA units, respectively; P <0.05, group I vs III). In those who did not respond, a significant (P < 0.02) lower helper/inducer (T 4)class of lymphocytes was observed as compared to patients who exhibited an adequate response. These observations suggest: (1) that the response to hepatitis B vaccine is a T-cell-dependent event and (2) that in this population, using the existing vaccine, postvaccination evaluations of antibody concentrations are needed before protection against hepatitis B infection can be assumed.

Key words

alcoholics hepatitis B vaccine anti-HBs helper T-lymphocytes