, Volume 14, Issue 1, pp 93-98

Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

cDNAs encoding human proteins C and S have been used to screen a panel of mouse-human somatic cell hybrids to determine the chromosomal location of their respective genes. The gene for human protein C is located on chromosome 2, whereas that for protein S is located on chromosome 3. Analysis of human genomic DNA restriction endonuclease fragmentation patterns suggests that the human protein S gene is greater than 40 kb in size and contains a minimum of 11 introns.