Article

Somatic Cell and Molecular Genetics

, Volume 15, Issue 4, pp 297-307

First online:

Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20

  • De-Hui KuAffiliated withDepartment of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
  • , Salvatore TravaliAffiliated withDepartment of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
  • , Bruno CalabrettaAffiliated withDepartment of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
  • , Kay HuebnerAffiliated withDepartment of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine
  • , Renato BasergaAffiliated withDepartment of Pathology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine

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Abstract

We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA)gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNAgene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter→Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12→6pter and probably represents a second pseudogene.