, Volume 10, Issue 2, pp 205-210

Regional assignment of human amylase (AMY) to p22 → p21 of chromosome 1

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Abstract

A human genomic DNA segment (λhal) which hybridizes with rat pancreatic amylase cDNA was used to regionally assign amylase genes in human-mouse somatic cell hybrids. The assignment of amylase genes to chromosome 1 was confirmed and regionally mapped to the short arm region p22.1→p21 using a cell hybrid retaining a translocation involving chromosome 1 [46,XX,t(1;2)(p21;q37)]. Restriction length polymorphisms at the amylase loci are reported for gene linkage studies.