Somatic Cell and Molecular Genetics

, Volume 13, Issue 6, pp 679–684

Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17

Authors

  • Naotoshi Kanda
    • Tokyo Women's Medical College
  • Shin-ichi Fukushige
    • Institute for Molecular and Cellular BiologyOsaka University
  • Tomoaki Murotsu
    • Institute for Molecular and Cellular BiologyOsaka University
  • Michihiro C. Yoshida
    • Chromosome Research UnitHokkaido University
  • Masayuki Tsuchiya
    • Institute of Medical ScienceUniversity of Tokyo
  • Shigetaka Asano
    • Institute of Medical ScienceUniversity of Tokyo
  • Yoshito Kaziro
    • Institute of Medical ScienceUniversity of Tokyo
  • Shigekazu Nagata
    • Institute of Medical ScienceUniversity of Tokyo
Brief Communication

DOI: 10.1007/BF01534488

Cite this article as:
Kanda, N., Fukushige, S., Murotsu, T. et al. Somat Cell Mol Genet (1987) 13: 679. doi:10.1007/BF01534488

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.

Copyright information

© Plenum Publishing Corporation 1987