Article

Journal of Autism and Developmental Disorders

, Volume 11, Issue 2, pp 219-230

Effects of pyridoxine and magnesium on autistic symptoms—Initial observations

  • G. LelordAffiliated withCentre Hospitalier Regionale de Tours
  • , J. P. MuhAffiliated withCentre Hospitalier Regionale de Tours
  • , C. BarthelemyAffiliated withCentre Hospitalier Regionale de Tours
  • , J. MartineauAffiliated withCentre Hospitalier Regionale de Tours
  • , B. GarreauAffiliated withCentre Hospitalier Regionale de Tours
  • , Enoch CallawayAffiliated withLangley Porter Psychiatric Institute, University of California

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Abstract

In an open trial, a heterogeneous group of 44 children with autistic symptoms were treated with large doses of vitamin B6 and magnesium. Clinical improvement with worsening on termination of the trial was observed in 15 children. Thirteen responders and 8 nonresponders were retested in a 2-week, crossover, double-blind trial, and the responses to the open trial were confirmed.