Clinical Rheumatology

, Volume 17, Issue 4, pp 329–332

Granulomatous amoebic encephalitis caused byAcanthamoeba in a patient with systemic lupus erythematosus

Authors

  • J. Koide
    • Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, Saitama
  • E. Okusawa
    • Department of Parasitology, School of MedicineKeio University
  • T. Ito
    • Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, Saitama
  • S. Mori
    • Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, Saitama
  • T. Takeuchi
    • Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, Saitama
  • S. Itoyama
    • Department of PathologySaitama Medical Centre, Saitama Medical School
  • T. Abe
    • Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, Saitama
Case Report

DOI: 10.1007/BF01451015

Cite this article as:
Koide, J., Okusawa, E., Ito, T. et al. Clin Rheumatol (1998) 17: 329. doi:10.1007/BF01451015

Abstract

A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused byAcanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection. The infectious encephalitis was difficult to differentiate from a flare-up of central nervous system lupus. This case illustrates thatAcanthamoeba can cause fatal encephalitis in lupus patients, as well as in patients with acquired immunodeficiency syndrome as previously reported. To our knowledge, this is the first reported case of granulomatous amoebic encephalitis due toAcanthamoeba in a patient with SLE.

Keywords

AcanthamoebaGranulomatous amoebic encephalitisOpportunistic InfectionSystemic lupus erythematosus

Copyright information

© Clinical Rheumatology 1998